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28.02.2016 - 16:54

Q.com article in the „Physik in unserer Zeit“

A recent open-access article by research partners from the BMBF Q.com Research Network project entitled "Sichere Kommunikation per Quantenrepeater" is published in "Physik in unserer Zeit", which reports on the current state and the main challenges in this field.

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12.12.2015 - 12:00

3rd OCL-TP Workshop

On 10-11th December, the 3rd International Workshop between the "Optical Communication Lab" and the Department "Technological Physics" took place under framework of long-term cooperation agreement between the Israel Institute of Technology and the University of Kassel.

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23.07.2015 - 16:54

OCL-TP Workshop

On 22-23rd July, the 2nd International Workshop between the "Optical Communication Lab" and the Department "Technological Physics" took place under framework of long-term cooperation agreement between the Israel Institute of Technology and the University of Kassel.

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INA - Technological Physics > Research > Nano Diamond > Projects Osseointegration

Ultrananocrystalline Diamond Coated Implants for Enhanced Osseointegration

As carbon is the basis of any biological system, carbon-based materials are ideal candidates for a wide range of biomedical and biotechnological applications, such as coatings of implants or surgical tools, for the development of biosensors and DNA chips, etc. In this research project we aim to make use of the superior mechanical, chemical and biological properties of ultrananocrystalline diamond (UNCD) films for the coating of bio-implants with enhanced osseointegration.

The UNCD coatings composed of diamond nanocrystallites of different sizes embedded in an amorphous carbon matrix will be prepared by microwave plasma chemical vapor deposition. The UNCD coatings will be deposited on various substrates, including titanium alloys for implants but also silicon and glass for different analyses and tests. The bulk properties of the coatings will be characterized with respect to their morphology, crystallinity and mechanical properties by a pool of techniques provided by both partners. In a next step, the surface of UNCD coatings will be modified and patterned. It is to be expected that the interaction of cells depends on the structure/feature size of the surface and on its chemistry. Therefore, by variation of these sizes and chemistries one can try to control these interactions. To meet this point the surfaces of UNCD will be modified by photochemical, plasma, ion beam or laser treatments by both partners, followed by a comprehensive characterization of their surface properties, such as roughness, wettability, and chemical surface termination. In order to create scaffold surfaces, the films will be patterned by lithographic and etching techniques.

The results from in vitro cell culture tests as well as genomic and proteomic analyses will allow to define the optimal interaction between the implanted material and the tissue on cellular and molecular levels which will lead to improvement of the osseointegration of the implants and shortening of the healing period.

Projekt Partners

  • Prof. Margarita D. Apstolova, Institute of Moleculöar Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Prof. Miroslav Jelinek, Dept. of Biomedical Engineering, Czech Technical University, Prague, Czech Republic
  • Dr. Giacomo Ceccone, Institute of Heath and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy

Selected publications

Picture gallery

Comparison of cell growth on as-grown and modified DLC and UNCD films obtained following MTT staining. The numbers in the bars indicate the doubling time in hours received following trypan blue staining and counting the cell number.
Fig. 1: Comparison of cell growth on as-grown and modified DLC and UNCD films obtained following MTT staining. The numbers in the bars indicate the doubling time in hours received following trypan blue staining and counting the cell number.
Immunofluorescent staining of fibronectin (green) released from endothelial progenitor cells undergoing transformation to osteoblasts on UNCD (A, C) and on hydrogel containing NCD (B, D). On day 7 following adhering (A, B)
Fig. 2: Immunofluorescent staining of fibronectin (green) released from endothelial progenitor cells undergoing transformation to osteoblasts on UNCD (A, C) and on hydrogel containing NCD (B, D).
Genotoxicity identified by Comet assay at 48 h following plaiting of MG-63 and EA.hy962 cells on different surfaces.
Fig. 3: Genotoxicity identified by Comet assay at 48 h following plaiting of MG-63 and EA.hy962 cells on different surfaces.
Localization of proteins of EA.hy962 plated on NH2-terminated UNCD identified by proteomics.
Fig. 4: Localization of proteins of EA.hy962 plated on NH2-terminated UNCD identified by proteomics.

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